Abstract: The preparation of a methacrylate polymer molecularly imprinted (MIP) with paracetamol (APAP) was performed. After extraction of the APAP template molecule, the MIPs were incorporated into a graphite-polyurethane (GPU) matrix, and the resulting composites were used to prepare modified electrodes intended to be used in APAP determination. The best results were found using a 2.5% MIP in the GPU electrode and a 500 μm MIP particle size. This electrode was used in the determination of APAP in pharmaceutical formulations, reaching a 6.7 x 10^-8 mol L^-1 limit of detection. The 2.5% MIP-GPU-modified electrode showed better sensitivity than the nonimprinted methacrylate GPU-modified electrodes. Interference of phenacetin in the APAP response decreased remarkably when the proposed electrode was used
Template and target information: paracetamol, APAP, acetominophen
Author keywords: DPV, graphite-polyurethane composite electrode, MIP, paracetamol